I have this problem too. I've an epson printer and have bought the cheaper generic cartridges. One day it will be working fine and the next I have to run the cleaning utility several times before I get any ink out at all! This tends to use up alot of ink.
You can get cleaner cartridges which flush out the heads but it doesn't seem to last long before it all clogs up again.
I know of another person who has the same problem. Think in future I will buy the epson ones although they are far more expensive at least you don't get all the hassle and don't waste so much ink either.
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